Share
Novel Developments in Cryo‐em of Biological Molecules: Resolution in Time and State Space (in English)
Joachim Frank
(Author)
·
Jenny Stanford Publishing
· Hardcover
Novel Developments in Cryo‐em of Biological Molecules: Resolution in Time and State Space (in English) - Frank, Joachim
$ 279.96
$ 349.95
You save: $ 69.99
Choose the list to add your product or create one New List
✓ Product added successfully to the Wishlist.
Go to My WishlistsIt will be shipped from our warehouse between
Wednesday, July 03 and
Friday, July 12.
You will receive it anywhere in United States between 1 and 3 business days after shipment.
Synopsis "Novel Developments in Cryo‐em of Biological Molecules: Resolution in Time and State Space (in English)"
Cryo-EM, as it is currently practiced in many laboratories, is limited to the visualization of molecules that are in thermal equilibrium at the time before freezing. A further limitation is that the existing software does not fully exploit the information that is contained in the images of large ensembles of molecules in thermal equilibrium. This book is a collection of recent articles by the author, reprinted with introductions, and they mainly describe two novel methods in cryo-EM, one computational and the other experimental that requires the use of a microfluidic device. Both methods have the capacity to shed light on the dynamic behavior of biomolecules. Combined, they greatly expand the range of applications of cryo-EM.The book describes a successful approach in which, based on cryo-EM data, all states visited by the molecule in thermal equilibrium are mapped by manifold embedding--a method of geometric machine learning--and the energy landscape of the molecule is derived. It also discusses methods and biological results of time-resolved cryo-EM, following a reaction in a non-equilibrium system over a short period of time and resulting in the capture of short-lived states that have been inaccessible by standard methods of cryo-EM.
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
All books in our catalog are Original.
The book is written in English.
The binding of this edition is Hardcover.
✓ Producto agregado correctamente al carro, Ir a Pagar.
