Share
Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs
Andrea Trabocchi
(Author)
·
Antonio Guarna
(Author)
·
Wiley
· Hardcover
Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs - Guarna, Antonio ; Trabocchi, Andrea
Out of Stock
We'll email you when the book is available again
Synopsis "Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs"
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
All books in our catalog are Original.
The book is written in English.
The binding of this edition is Hardcover.
✓ Producto agregado correctamente al carro, Ir a Pagar.
