Name: Cancer Metastasis -- Related Genes (in English)
Price: 161.04 USD
Availability: InStock
Author: Welch, D. R.
ISBN: 9789401739221

portada Cancer Metastasis -- Related Genes (in English)

Type

Physical Book

Publisher

Springer

Author

Welch, D. R.

Language

Inglés

Pages

270

Format

Paperback

Dimensions

23.4 x 15.6 x 1.5 cm

Weight

0.41 kg.

ISBN13

9789401739221

Synopsis "Cancer Metastasis -- Related Genes (in English)"

Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e.,