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portada immunogenicity of biopharmaceuticals (in English)
Type
Physical Book
Publisher
Year
2010
Language
English
Pages
266
Format
Paperback
Dimensions
25.4 x 17.8 x 1.5 cm
Weight
0.49 kg.
ISBN
1441926089
ISBN13
9781441926081

immunogenicity of biopharmaceuticals (in English)

Marco Weert (Illustrated by) · Eva Horn Møller (Illustrated by) · Springer · Paperback

immunogenicity of biopharmaceuticals (in English) - Weert, Marco ; Møller, Eva Horn

Physical Book

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Synopsis "immunogenicity of biopharmaceuticals (in English)"

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho's blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies. This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

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