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Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery (in English)
Rai, Ravishankar V. ; Bai, Jamuna A. (Author)
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Springer
· Hardcover
Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery (in English) - Rai, Ravishankar V. ; Bai, Jamuna a.
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Synopsis "Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery (in English)"
Section 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis. Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment). Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains. Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes. Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level. Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes. Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites. Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes. Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes. Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes. Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes. Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research. Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites. Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters. Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production Chapter 18: Synthetic biology in Actinomycetes for natural product discovery Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.
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The book is written in English.
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